Many UA life sciences researchers use the CyVerse project to manage and share data and run large or complex analyses and simulations. The AGAVE Platform allows integration of UA High Performance Computing and Storage resources with the easy-to-use CyVerse Discovery Environment. Since UA HPC systems allow longer job running times and may have shorter job queue wait times than other HPC systems accessible through CyVerse, using AGAVE to submit Discovery Environment jobs to UA HPC could be beneficial to those who need to run Bayesian analyses or large BLAST searches. Using AGAVE, researchers interested in large genome assembly and annotation can access UA HPC high memory nodes through the Discovery Environment, running jobs through a Graphical User Interface rather than the Linux command line. We will demonstrate how to use AGAVE tools to create an application that can be launched from the CyVerse Discovery Environment and run on UA HPC systems.